Applied Bioinformatics Group

Department of Biotechnology - University of Verona

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The Applied Bioinformatics group (PI Dr. Alejandro Giorgetti) is interested principally to arguments related to Protein Structural Bioinformatics.

The main interests and the principal activities of the group include: protein modeling from sequence, in particular using comparative modeling techniques; protein structure analysis; protein sequence analysis; protein design; and the development of tools aimed at the investigation and understanding of the relationship between protein sequence, structure and function, in particular in systems that include membrane proteins.

The group applies state-of-art algorithms/programs/techniques in cases of biological interest.

Specific projects include:

  • Structural Neuroinformatics: Modelling of proteins/receptors of neurological interest. Those include

a) Receptors involved in chemoperception: Bitter taste receptors and olfactory receptors.

b) Receptors involved in neurodegenerative diseases: GPR3 receptors.

c) Oxytocin receptors.

d) Development of multiscale approaches aimed at gaining insights into the structure function of receptors of           neurobiological interest: GOMoDo server for modelling and docking of GPCR receptors and the coarse- grained/molecular mechanics (CG/MM) hybrid approach

  • Chemoinformatics: Deorphanizing olfactory receptors by the use of bioinformatics techniques and chemoinformatic approaches.


  • Membrane protein modelling at genomic level: My group counts with an important expertise in the field of membrane protein modelling, comprising the modelling of mammalian ion channels (CNG and HCN), modelling of odorant and bitter taste receptors (GPCR), modelling of efflux pumps.


  • Interaction of HIV-1 proteins with its human counterpart, i.e. hTE8/Nef and HLA-C/env.

 

The GPCR modeling is within a collaborative project with the Computational Biophysics laboratory of the German Research School for Simulation Sciences. Indeed, Alejandro Giorgetti helps in the coordination of the GPCR Lab as a official visiting scientist.